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Фармакокинетика и Фармакодинамика

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Кардиопротекторные средства с биароматической структурой. Часть 2. Блокаторы HCN-каналов

https://doi.org/10.37489/2587-7836-2022-2-03-10

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Аннотация

Управляемые циклическими нуклеотидами гиперполяризационно-активируемые каналы (HCN-каналы), прежде всего, их HCN4-подтип, являются одной из перспективных мишеней для разработки кардиопротекторных средств. Блокаторы HCN-каналов обладают селективным брадикардическим действием, сохраняя сократимость миокарда и диастолическую функцию и не оказывая влияния на электрофизиологические параметры сердца. Настоящий обзор продолжает серию обзоров по анализу соединений с кардиопротекторными свойствами в ряду биароматических структур, к которым относится и широкий ряд блокаторов HCN-каналов.

Об авторе

Г. В. Мокров
ФГБНУ «НИИ фармакологии имени В.В. Закусова»
Россия

Мокров Григорий Владимирович, к. х. н., в. н. с. лаборатории тонкого органического синтеза отдела химии лекарственных средств. SPIN-код: 8755-7666

Москва



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Рецензия

Для цитирования:


Мокров Г.В. Кардиопротекторные средства с биароматической структурой. Часть 2. Блокаторы HCN-каналов. Фармакокинетика и Фармакодинамика. 2022;(2):3-10. https://doi.org/10.37489/2587-7836-2022-2-03-10

For citation:


Mokrov G.V. Сardioprotective agents with biaromatic structure. Part 2. HCN channel blockers. Pharmacokinetics and Pharmacodynamics. 2022;(2):3-10. (In Russ.) https://doi.org/10.37489/2587-7836-2022-2-03-10

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ISSN 2587-7836 (Print)
ISSN 2686-8830 (Online)