An experimental study of the systemic bioavailability of the drug "Harmin hydrochloride, capsules" in comparison with native garmin on chinchilla rabbits

Abstract

An experimental comparative study of the relative bioavailability of plant alkaloid harmine (native, in the form of a base) in comparison with its derivative harmine hydrochloride was carried out on chinchilla rabbit. Both substances was administered in capsules, containing an equimolar amount of harmine (50 mg, p.o.). Harmin hydrochloride was shown to have some pharmacokinetic advantages in comparison with native harmin due to a relatively rapid achievement of the maximal plasma concentration (T_max) and a significantly higher maximum concentration of the active substance in the blood. At the same time, there was shown that the chemical modification of harmine does not significantly affect on such pharmacokinetics parameter as the area under the curve (AUC), which indicates the absence of a difference in the degree of absorption in the compared dosage forms.