The in vitro neuroprotective activity of analogues of N-terminus substituted glyprolines
https://doi.org/10.37489/2587-7836-2020-2-4-10
Abstract
In this work investigated the neuroprotective activity of analogues of substituted glyproline GZK-111 at the N-terminus in vitro. Oxidative stress caused by H2O2 (1.5 mM) led to significant decrease in the hippocampal cells HT-22 viability. The ethyl ester N-phenypropionyl-glycyl-proline (GZK-45) was effective at the concentrations up to 10–6 M in both experimental schemes. The compounds with N-acethyl (GZK-49) and N-capronoyl (GZK-46) fragments did not protective effect in both experimental schemes. GZK-45 also had protective effect in the 6-hydroxydopamine induced damage of SH-SY5Y neuroblastoma cells.
Keywords
About the Authors
S. V. Nikolaev
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Nikolaev Sergey V. – Research Scientist, Neuroprotection pharmacology laboratory. SPIN code: 7723-6008
Moscow
I. O. Logvinov
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Logvinov Ilya O. – Research Scientist, Neuroprotection pharmacology laboratory. SPIN code: 9909-9630
Moscow
K. N. Koliasnikova
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Koliasnikova Ksenia N. – Research Scientist, Laboratory of peptide bioregulators, Department of medicinal chemistry. SPIN code: 5682-2035
Moscow
E. A. Kuznetsova
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Kuznetsova Elena A. –PhD, Senior Research Scientist, Laboratory of fine organic synthesis, Department of medicinal chemistry
Moscow
P. I. Antipov
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Antipov Petr I. – PhD, Senior Research Scientist, Laboratory of peptide bioregulators, Department of medicinal chemistry. SPIN code: 2591-3379
Moscow
T. A. Antipova
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Antipova Tatyana A. – PhD, Head Neuroprotection pharmacology laboratory. SPIN-код: 7723-6008
Moscow
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Review
For citations:
Nikolaev S.V., Logvinov I.O., Koliasnikova K.N., Kuznetsova E.A., Antipov P.I., Antipova T.A. The in vitro neuroprotective activity of analogues of N-terminus substituted glyprolines. Pharmacokinetics and Pharmacodynamics. 2020;(2):4-10. (In Russ.) https://doi.org/10.37489/2587-7836-2020-2-4-10
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