Study of chronic toxicity of the GB-115 drug formulation
https://doi.org/10.37489/2587-7836-2019-4-37-44
Abstract
The results of the study of chronic toxicity of the drug formulation of anxiolytic GB-115 are presented. The novel dipeptide in the form of a tablet mass was administered daily orally for 6 months to outbred rats and rabbits of the chinchilla breed at a dose of 1 mg/kg corresponding to the therapeutic and 50 mg/kg exceeding the therapeutic dose by 50 times. Clinical, laboratory and pathohistological studies performed in accordance with the General Protocol demonstrated the absence of toxic effects of the GB-115 drug formulation. The exception was the reversible changes in the coagulation activity in rats and rabbits, which were not associated with the dose of the GB-115 solid dosage from.
About the Authors
A. V. Sorokina
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Sorokina Aleksandra, Candidate of Biological Sciences, Leading researcher of the laboratory of drug toxicology, Moscow
Russian Federation
Sorokina Aleksandra, Candidate of Biological Sciences, Leading researcher of the laboratory of drug toxicology, Moscow
S. V. Alekseeva
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Alekseeva Svetlana, SPIN code: 8985-3418, Senior Research Officer of laboratory of drug toxicolog, Moscow
I. A. Miroshkina
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Miroshkina Irina, SPIN code: 4697-7938, Research scientist of the laboratory of drug toxicology, Moscow
V. V. Zabrodina
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Zabrodina Victoria, SPIN code: 8473-6920, Candidate of Biological Sciences, Research scientist of the laboratory of drug toxicology, Moscow
L. G. Kolik
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Kolik Larisa, Doctor of Biological Sciences, prof. RAS, Head Laboratory of Pharmacological Regulation of Alcohol and Drug Addiction, Moscow
A. D. Durnev
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Durnev Andrei, SPIN code: 8426-0380, RAS corresponding member, Doctor of Biological Sciences., Head of the laboratory of drug toxicology, Professor, Director, Moscow
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Review
For citations:
Sorokina A.V., Alekseeva S.V., Miroshkina I.A., Zabrodina V.V., Kolik L.G., Durnev A.D. Study of chronic toxicity of the GB-115 drug formulation. Pharmacokinetics and Pharmacodynamics. 2019;(4):37-44. (In Russ.) https://doi.org/10.37489/2587-7836-2019-4-37-44
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