Therapeutic drug monitoring of methotrexate after its administration in high doses for osteosarcoma treatment in children

In children oncology high doses of methotrexate (HD Mtx) use for treatment of osteosarcoma, acute lymphoblastic leukemia and many others tumors. Due to high intra- and interindividual Mtx pharmacokinetic variability it is essential perform monitoring its concentration in the saliva. The most dangerous phenomena in the case of HD Mtx are so-termed "delayed Mtx excretion", "prolonged Mtx excretion". Their development is multifactorial and unpredictable. Having big actual material we set task: analyze pharmacokinetics HD Mtx in case of osteosarcoma in children, determine its peculiarities, elucidate whether similar or not proceed disorders of Mtx excretion, perform their quantification.

дети, высокие дозы метотрексата, онкология, терапевтический лекарственный мониторинг, токсико-кинетика, токсичность, children, high doses of Methotrexate, oncology, therapeutic drug monitoring, toxicokinetics, toxicity, children, high doses of Methotrexate, oncology, therapeutic drug monitoring, toxicokinetics, toxicity

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