HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», Russia
Abstract
A simple, specific, sensitive and reproducible good method for quantitative determination of Levofloxacin in plasma using HPLC with UV-spectrophotometric detection. With this technique the pharmacokinetics and relative bioavailability of domestic generic of levofloxacin in 18 healthy volunteers after a single oral dose of 500 mg. Found that the drug being tested, levofloxacin (OOO «Ozone», Russia) is bioequivalent to the reference drugs Tavanic® («Sanofi Winthrop Industry», France).
About the Authors
S. N. Kondratenko
First Moscow State Medical University I.M. Sechenov
Russian Federation
Russian Federation
A. K. Starodubtcev
First Moscow State Medical University I.M. Sechenov
Russian Federation
Russian Federation
E. A. Senik
First Moscow State Medical University I.M. Sechenov
Russian Federation
Russian Federation
O. V. Dralova
First Moscow State Medical University I.M. Sechenov
Russian Federation
Russian Federation
S. N. Kudinova
First Moscow State Medical University I.M. Sechenov
Russian Federation
Russian Federation
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Review
For citations:
Kondratenko S.N., Starodubtcev A.K., Senik E.A., Dralova O.V., Kudinova S.N. HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», Russia. Pharmacokinetics and Pharmacodynamics. 2013;(1):23-26. (In Russ.)
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