phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»phkinetica-7Research ArticleПРОТЕОМНЫЙ АНАЛИЗPROTEOMIC ANALYSISСинергидные нейропротекторные эффекты тиамина, пиридоксина и цианокобаламина в рамках протеома человекаSynergistic neuroprotective effects of thiamine, pyridoxine and cyanocobalamin on the level of human proteomeГромоваОльга АлексеевнаGromovO. A.unesco.gromova@gmail.comТоршинИ. Ю.TorshinI. Yu.noemail@neicon.ruГусевЕ. И.GusevE. I.noemail@neicon.ruФГБОУ ВО «Ивановская государственная медицинская академия»; РСЦ Института Микроэлементов ЮНЕСКО при ФГБОУ ВПО РНИМУ им Н.И. ПироговаРоссия«Ivanovo State Medical Academy»; RIC Institute of trace elements at UNESCO VPO Rnrmu them NI PirogovRussian FederationРСЦ Института Микроэлементов ЮНЕСКО при ФГБОУ ВПО РНИМУ им Н.И. ПироговаРоссияRIC Institute of trace elements at UNESCO VPO Rnrmu them NI PirogovRussian Federation201706022017014051Copyright © Громова О.А., Торшин И.Ю., Гусев Е.И., 20172017Громова О.А., Торшин И.Ю., Гусев Е.И.Gromov O.A., Torshin I.Y., Gusev E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/7

Витамины группы В характеризуются нейропротекторными эффектами. Механизмы синергидного действия различных комбинаций витаминов недостаточно изучены. В настоящем исследовании в геномных и протеомных базах данных были найдены белки, активность или уровни которых взаимосвязаны с обеспеченностью организма витаминами В1 (тиамин), В6 (пиридоксин) и В12 (цианокобаламин). Системно-биологический анализ показал, что тиамин необходим для синтеза АТФ (в т. ч. посредством метаболизма глюкозы, липидов и аминокислот с разветвленной цепью), кроветворения и для роста и поддержания структуры нейронов. Пиридоксин-зависимые белки протеома необходимы для метаболизма аминокислот, синтеза АТФ, синтеза нейротрансмиттеров и мембран нейронов. Витамин В12 необходим для метаболизма липидов, кроветворения и проявляет нейропротекторный и нейротрофический эффекты. Выявлены многочисленные синергидные взаимодействия витаминов В1, В6, В12 на молекулярном уровне, включающие метаболизм аминокислот, углеводов, липидов, формирование структур нейронов, кроветворение, синтез АТФ и др. Установленные механизмы синергизма витаминов В1, В6, В12 на молекулярном уровне имеют фундаментальное значение для нейропротекции и профилактики цереброваскулярной патологии.

Group B vitamins are characterized by neuroprotective effects. Mechanisms of action of synergistic combinations of various vitamins are insufficiently studied. In this study, proteins with activity or levels dependent on vitamins B1 (thiamine), B6 (pyridoxine) and B12 (cyanocobalamin) were found in genomic and proteomic databases. Systems biology analysis showed that the thiamine is necessary for synthesis of ATP (glucose metabolism, lipid and branched chain amino acids), hemopoiesis and maintenance of neuronal structure. Pyridoxine-dependent proteins of the proteome are necessary for the metabolism of amino acids, ATP synthesis, synthesis of neurotransmitters and of neuronal membranes. Vitamin B12 is needed for the metabolism of lipids, hemopoiesis and shows neuroprotective and neurotrophic effects. We identified numerous synergistic interactions of vitamins B1, B6, B12, at the molecular level, including the metabolism of amino acids, carbohydrates, lipids, forming structures of neurons, blood, ATP synthesis etc. The established mechanisms of vitamins B1, B6, B12 synergy at the molecular level are of fundamental importance for neuroprotection and prevention of cerebrovascular disease.

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The authors declare that there are no conflicts of interest present.