phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»10.37489/2587-7836-2025-1-17-26VWHUHMphkinetica-446Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESФерроптоз и старениеFerroptosis and ageinghttps://orcid.org/0009-0001-6673-554XГаранинА. А.GaraninA. A.

Гаранин Алексей Алексеевич — ассистент кафедры фармакологии ФГБОУ ВО Ивановский ГМУ Минздрава России.

Иваново

Alexey A. Garanin — Associate Professor of the Department of Pharmacology of the FSBEI HE «Ivanovo SMU» of MOH of Russia.

Ivanovo

alexgaranin@icloud.comhttps://orcid.org/0000-0002-5042-4886БогачеваТ. Е.BogachevaT. E.

Богачева Татьяна Евгеньевна — к. м. н., доцент кафедры фармакологии ФГБОУ ВО ИвГМА Минздрава России.

Иваново

Tatiana E. Bogacheva — PhD, Cand. Sci. (Med.), Associate Professor of the Department of Pharmacology of the FSBEI HE IvSMA MOH Russia.

Ivanovo

https://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна — профессор кафедры фармакологии ФГБОУ ВО Ивановский ГМУ Минздрава России; д. м. н, профессор, в. н. с. ФИЦ ИУ РАН.

Иваново; Москва

Olga A. Gromova — Professor of the Department of Pharmacology FSBEI HE «Ivanovo SMU» of MOH of Russia; Dr. Sci. (Med.), Professor, Leading researcher FRC CSC RAS.

Ivanovo; Moscow

ФГБОУ ВО «Ивановский государственный медицинский университет» Минздрава РоссииРоссияIvanovo State Medical University of MOH of RussiaRussian Federation202523052025011726Copyright © Гаранин А.А., Богачева Т.Е., Громова О.А., 20252025Гаранин А.А., Богачева Т.Е., Громова О.А.Garanin A.A., Bogacheva T.E., Gromova O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/446

Ферроптоз — это регулируемая форма гибели клеток, характеризующаяся железозависимым перекисным окислением липидов. С момента своего первоначального описания он привлёк значительное внимание из-за его последствий при различных заболеваниях, включая рак, нейродегенерацию и ишемически-реперфузионное повреждение. Процесс старения характеризуется прогрессирующим снижением клеточной функции и повышенной восприимчивостью к окислительному повреждению, оба из которых пересекаются с путями ферроптоза. В этом обзоре исследуется сложная связь между ферроптозом и старением, с упором на молекулярные механизмы, роль метаболизма железа, последствия при возрастных заболеваниях и потенциальные терапевтические стратегии. Понимая взаимодействие между ферроптозом и старением, исследователи могут обнаружить новые цели для содействия здоровому старению и смягчения возрастных расстройств.

Ferroptosis is a regulated form of cell death characterized by iron-dependent lipid peroxidation. Since its initial description, it has garnered significant attention due to its implications in various diseases, including cancer, neurodegeneration, and ischemia-reperfusion injury. The ageing process is characterized by a progressive decline in cellular function and increased susceptibility to oxidative damage, both of which intersect with ferroptosis pathways. This review explores the intricate relationship between ferroptosis and ageing, focusing on molecular mechanisms, the role of iron metabolism, implications in age-related diseases, and potential therapeutic strategies. By understanding the interplay between ferroptosis and ageing, researchers can uncover novel targets for promoting healthy ageing and mitigating age-associated disorders.

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The authors declare that there are no conflicts of interest present.