phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»10.37489/2587-7836-2024-4-17-21VMQTRDphkinetica-434Research ArticleОБЗОРЫREVIEWSЭкспериментальные модели старенияExperimental models of aginghttps://orcid.org/0009-0001-6673-554XГаранинА. А.GaraninA. A.

Гаранин Алексей Алексеевич – ассистент кафедры фармакологии

Иваново

Alexey A. Garanin – Assistant Professor, Chair of Pharmacology

Ivanovo

alexgaranin@icloud.comhttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна – д. м. н, профессор кафедры фармакологии; в. н. с.

Иваново;

Москва

Olga A. Gromova – Dr. Sci. (Med.), Professor of the Department of Pharmacology

Ivanovo;

Moscow

 

https://orcid.org/0000-0002-5042-4886БогачеваТ. Е.BogachevaT. E.

Богачева Татьяна Евгеньевна – к. м. н., доцент кафедры фармакологии

Иваново

Tatiana E. Bogacheva – PhD, Cand. Sci. (Med.), Associate Professor of the Department of Pharmacology

Ivanovo

ФГБОУ ВО «Ивановский государственный медицинский университет» Минздрава РоссииРоссияIvanovo State Medical University of MOH of RussiaRussian FederationФГБОУ ВО «Ивановский государственный медицинский университет» Минздрава России; ФГУ «Федеральный исследовательский центр «Информатика и управление» РАН (ФИЦ ИУ РАН)РоссияIvanovo State Medical University of MOH of Russia; Federal Research Center «Computer Science and Control»Russian Federation202425012025041721Copyright © Гаранин А.А., Громова О.А., Богачева Т.Е., 20252025Гаранин А.А., Громова О.А., Богачева Т.Е.Garanin A.A., Gromova O.A., Bogacheva T.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/434

Старение – это результат сочетанных изменений во многих биологических процессах, которые связаны с нарушением функционального состояния у людей и повышают риск хронических патологий. Поскольку существует ряд непреодолимых трудностей в проведении клинических исследований на людях, приходится прибегать к экспериментальному моделированию ключевых признаков старения и связанных с ним патологий.

Однако все используемые модели старения далеко не совершенны, поскольку существует целый ряд факторов, которые не позволяют полностью сопоставить механизмы процесса старения у человека и животных. В этой статье приведены основные экспериментальные модели старения и определены их преимущества и недостатки в контексте потенциальных исследований.

Aging is the result of combined changes in many biological processes that are associated with impaired functional status in humans and increase the risk of chronic pathologies. Since there are a number of insurmountable difficulties in conducting clinical studies on humans, it is necessary to resort to experimental modeling of key signs of aging and associated pathologies.

However, all the used models of aging are far from perfect, since there are a number of factors that do not allow a full comparison of the mechanisms of the aging process in humans and animals. This article presents the main experimental models of aging and determines their advantages and disadvantages in the context of potential studies.

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The authors declare that there are no conflicts of interest present.