phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»10.37489/2587-7836-2023-3-3-11phkinetica-376Research ArticleАКТУАЛЬНЫЕ ОБЗОРЫCURRENT REVIEWSКардиопротекторные средства с биароматической структурой. Часть 6. Бета-блокаторыСardioprotective agents with biaromatic structure. Part 6. Beta blockershttps://orcid.org/0000-0003-2617-0334МокровГ. В.MokrovG. V.

Мокров Григорий Владимирович - к. х. н., в. н. с. лаборатории тонкого органического синтеза отдела химии лекарственных средств

Москва

Grigory V. Mokrov - PhD, Cand. Chemical Sci., Leading researcher of the fine organic synthesis laboratory at the drug chemistry department

Moscow

g.mokrov@gmail.comФГБНУ «НИИ фармакологии имени В.В. Закусова»РоссияFSBI “Zakusov Institute of Pharmacology”Russian Federation20230211202303311Copyright © Мокров Г.В., 20232023Мокров Г.В.Mokrov G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/376

β-Адреноблокаторы — один из старейших классов кардиопротекторов, применяемых при лечении сердечно-сосудистых заболеваний. Они уменьшают частоту сердечных сокращений, имеют гипотензивное действие, угнетают сократимость миокарда и обладают антиаритмическими свойствами. В ряду биароматических соединений с линейным линкером имеется достаточно обширная группа β-блокаторов, которые помимо двух ароматических ядер содержат в линкере 1,2-дигидрокси-3-аминопропановый фрагмент — ключевой для наличия β-блокирующей активности. Среди соединений этой группы имеются широко применяемые препараты небиволол и карведилол, которые используются при терапии хронической сердечной недостаточности и артериальной гипертензии.

β-Blockers are one of the oldest classes of cardioprotectors used in the treatment of cardiovascular diseases. They reduce the heart rate, have a hypotensive effect, inhibit myocardial contractility and have antiarrhythmic properties. In the series of biaromatic compounds with a linear linker, there is a quite large group of β-blockers, which in addition to two aromatic nuclei contain a 1,2-dihydroxy-3-aminopropane fragment in the linker, that is the key for the presence of β-blocking activity. Among the compounds of this group are widely used drugs nebivolol and carvedilol, which are used in the treatment of chronic heart failure and arterial hypertension.

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The authors declare that there are no conflicts of interest present.