phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»10.37489/2587-7836-2022-2-11-16phkinetica-313Research ArticleИССЛЕДОВАНИЯ МЕХАНИЗМА ДЕЙСТВИЯMECHANISM OF ACTION RESEARCHВлияние максимального электрошока и противосудорожных препаратов на концентрацию продуктов перекисного окисления липидов в эксперименте на мышахThe effect of maximal electroshock seizure and anticonvulsants on the concentration of lipid peroxidation products in an experiment in micehttps://orcid.org/0000-0002-8056-4142ГайдуковИ. О.GaydukovI. O.

Гайдуков Игорь Олегович, к. б. н., с. н. с. лаборатории психофармакологии

Москва

Gaydukov Igor O., PhD Biological Sci., Senior researcher of laboratory psychopharmacology

Moscow

gaidukov01@rambler.ruhttps://orcid.org/0000-0001-9139-2334ЛитвиноваС. А.LitvinovaS. A.

Литвинова Светлана Александровна, к. б. н., в. н. с. лаборатории психофармакологии

Москва

Litvinova Svetlana A., PhD Biological Sci., Leading researcher Laboratory of Psychopharmacology

Moscow

sa_litvinova@mail.ruhttps://orcid.org/0000-0003-3528-4659ЗолотовН. Н.ZolotovN. N.

Золотов Николай Николаевич, д. б. н., профессор, гл. н. с, лаборатории психофармакологии

Москва

Zolotov Nikolay N., Dr. Sci. Biological, professor, Chief researcher of laboratory psychopharmacology

Moscow

zolotovnn@gmail.comhttps://orcid.org/0000-0001-7083-5298КотельниковаС. О.KotelnikovaS. O.

Котельникова Светлана Олеговна, к. б. н., с. н. с. лаборатории психофармакологии

Москва

Kotelnikova Svetlana O., PhD Biological Sci., Senior researcher, laboratory of psychopharmacology

Moscow

ailantha@mail.ruhttps://orcid.org/0000-0002-3566-6203ВоронинаТ. А.VoroninaT. A.

Воронина Татьяна Александровна, д. м. н., профессор, руководитель лаборатории психофармакологии. SPIN-код: 5766-3452

Москва

Voronina Tatiana A., Dr. Sci. (Med.), professor, Head Laboratory of psychopharmacology. SPIN code: 5766-3452

Moscow

voroninata38@gmail.comФГБНУ «НИИ фармакологии имени В.В. Закусова»РоссияFSBI “Zakusov Institute of Pharmacology”Russian Federation202206072022021116Copyright © Гайдуков И.О., Литвинова С.А., Золотов Н.Н., Котельникова С.О., Воронина Т.А., 20222022Гайдуков И.О., Литвинова С.А., Золотов Н.Н., Котельникова С.О., Воронина Т.А.Gaydukov I.O., Litvinova S.A., Zolotov N.N., Kotelnikova S.O., Voronina T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/313

Окислительный стресс играет одну из ключевых ролей в эпилептогенезе. Целью исследования было оценить влияние судорог на развитие оксидативного стресса и наличие антиоксидантных свойств у карбамазепина и вальпроевой кислоты при судорожном состоянии, вызванном максимальным электрошоком (МЭШ). Методы. У мышей вызывали электросудорожные припадки методом МЭШ с оценкой тяжести судорог по балльной шкале. Оценку оксидативного стресса проводили по продуктам перекисного окисления липидов (ПОЛ), определяемых в плазме крови. Результаты. Установлено, что воздействие МЭШ с последующими тонико-клоническими припадками приводит к оксидативному стрессу у мышей. Вальпроевая кислота и карбамазепин полностью защищали от возникновения судорог после воздействия МЭШ, однако концентрация продуктов ПОЛ не отличалась от группы с МЭШ и была также выше, чем в группе контроля.

Oxidative stress plays a key role in epileptogenesis. The aim of the study was to evaluate the effect of seizures on the development of oxidative stress and the presence of antioxidant properties in carbamazepine and valproic acid in convulsive state caused by maximal electroshock seizure (MES). Methods. An electroconvulsive seizure were induced by the MES-test in mice, with assessment of the severity of seizures on a point scale. Oxidative stress was assessed by products of lipid peroxidation (LPO) determined in blood plasma. Results. It has been established that exposure to MES followed by tonic-clonic seizures leads to oxidative stress in mice. Valproic acid and carbamazepine completely protected against seizures after MES-test, however, the concentration of lipid peroxidation products did not differ from the MES group and was also higher than in the control group.

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The authors declare that there are no conflicts of interest present.