phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»10.37489/2587-7836-2022-2-03-10phkinetica-312Research ArticleАКТУАЛЬНЫЕ ОБЗОРЫCURRENT REVIEWSКардиопротекторные средства с биароматической структурой. Часть 2. Блокаторы HCN-каналовСardioprotective agents with biaromatic structure. Part 2. HCN channel blockershttps://orcid.org/0000-0003-2617-0334МокровГ. В.MokrovG. V.

Мокров Григорий Владимирович, к. х. н., в. н. с. лаборатории тонкого органического синтеза отдела химии лекарственных средств. SPIN-код: 8755-7666

Москва

Mokrov Grigory V., PhD Chemical Sci., Leading researcher of the fine organic synthesis laboratory at the drug chemistry department. SPIN code: 8755-7666

Moscow

g.mokrov@gmail.comФГБНУ «НИИ фармакологии имени В.В. Закусова»РоссияFSBI “Zakusov Institute of Pharmacology”Russian Federation20220607202202310Copyright © Мокров Г.В., 20222022Мокров Г.В.Mokrov G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/312

Управляемые циклическими нуклеотидами гиперполяризационно-активируемые каналы (HCN-каналы), прежде всего, их HCN4-подтип, являются одной из перспективных мишеней для разработки кардиопротекторных средств. Блокаторы HCN-каналов обладают селективным брадикардическим действием, сохраняя сократимость миокарда и диастолическую функцию и не оказывая влияния на электрофизиологические параметры сердца. Настоящий обзор продолжает серию обзоров по анализу соединений с кардиопротекторными свойствами в ряду биароматических структур, к которым относится и широкий ряд блокаторов HCN-каналов.

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels, primarily their HCN4 subtype, are one of the promising targets for the development of cardioprotective agents. HCN channel blockers have a selective bradycardic effect, preserving myocardial contractility and diastolic function and not affecting the electrophysiological parameters of the heart. This review continues a series of reviews on the analysis of compounds with cardioprotective properties in a number of biaromatic structures, which include a wide range of HCN channel blockers.

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The authors declare that there are no conflicts of interest present.