phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»10.37489/2587-7836-2022-1-44-54phkinetica-308Research ArticleФАРМАКОКИНЕТИЧЕСКИЕ ИССЛЕДОВАНИЯPHARMACOKINETIC RESEARCHESПрименение метода AlphaScreen и AlphaLisa в разработке лекарственных препаратов и фармакокинетических исследованияхApplication of the AlphaScreen and AlphaLisa method in drug development and pharmacokinetic studieshttps://orcid.org/0000-0001-6170-5221МухаметшинаР. Т.MukhametshinaR. T.

Регина Талгатовна Мухаметшина, к. б. н., м. н. с.

Владимирская область

Regina T. Mukhametshina, PhD Biological Sci., junior researcher

Vladimir region

rtmukhametshina@ibcgenerium.ruhttps://orcid.org/0000-0003-1176-5829КопеинД. С.KopeinS. D.

Дамир Сергеевич Копеин, к. б. н., н. с.

Владимирская область

Damir S. Kopein, PhD Biological Sci., research scientist

Vladimir region

kopein@ibcgenerium.ruhttps://orcid.org/0000-0002-0879-5595СимоновВ. М.SimonovV. M.

Владимир Михайлович Симонов, с. н. с.

Владимирская область

Vladimir M. Simonov, senior researcher

Vladimir region

simonov@ibcgenerium.ruАкционерное Общество "ГЕНЕРИУМ"РоссияJoint Stock Company "GENERIUM"Russian Federation202201052022014454Copyright © Мухаметшина Р.Т., Копеин Д.С., Симонов В.М., 20222022Мухаметшина Р.Т., Копеин Д.С., Симонов В.М.Mukhametshina R.T., Kopein S.D., Simonov V.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/308

   Разработка лекарственных препаратов нуждается в высокотехнологичных, простых и чувствительных методах. Метод AlphaLISA является универсальным методом, который подходил бы под перечисленные критерии. Однако анализ работ по фармакокинетике лекарственных препаратов, имеющих отношение к данному методу, демонстрирует незначительное количество фармакокинетических исследований при клинических испытаниях. В данной статье мы раскрываем не только положительные стороны метода Alpha, но и его недостатки.

   Drug development requires high-tech, simple, and sensitive methods. AlphaLISA method was announced as a universal method that would fit the listed criteria. However, research of other works on the pharmacokinetics of drugs related to this method showed a small number of pharmacokinetic studies in clinical trials. In this review, we focused on not only the positive aspects of the Alpha method, but also its disadvantages.

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The authors declare that there are no conflicts of interest present.