phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»10.37489/2587-7836-2021-3-3-11phkinetica-288Research ArticleОБЗОРЫREVIEWSПерспективы применения препаратов адамантанового ряда для лечения цереброваскулярных и сердечно-сосудистых заболеванийPerspective for the use of adamantane-type drugs for the treatment of cerebrovascular and cardiovascular diseaseshttps://orcid.org/0000-0001-6888-3223АбаимовД. А.AbaimovD. A.

Абаимов Денис Александрович - к. б. н., с. н. с. лаборатории гемореологии, гемостаза и фармакокинетики с клинической и лабораторной диагностикойSPIN-код: 7548-0933 

Москва

Abaimov Denis A. - PhD in Biology, Senior Researcher at the Laboratory of Hemorheology, Hemostasis and Pharmacokinetics with clinical and laboratory diagnosticsSPIN code: 7548-0933

Moscow

abaidenis@yandex.ruhttps://orcid.org/0000-0001-7393-0979ШабалинаА. А.ShabalinaA. A.

Шабалина Алла Анатольевна - к. м. н., заведующая лабораторией гемореологии, гемостаза и фармакокинетики с клинической и лабораторной диагностикойSPIN-код: 9414-9068

Москва

Shabalina Alla A. - PhD in Medicine, Head of the Laboratory of Hemorheology, Hemostasis and Pharmacokinetics with clinical and laboratory diagnosticsSPIN code: 9414-9068

Moscow

ashabalina@yandex.ruФедеральное государственное бюджетное научное учреждение "Научный центр неврологии"РоссияResearch Center of NeurologyRussian Federation20211402202203311Copyright © Абаимов Д.А., Шабалина А.А., 20222022Абаимов Д.А., Шабалина А.А.Abaimov D.A., Shabalina A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/288

Препараты адамантановго ряда широко применяются в фармакологии в качестве антимикробных, противоопухолевых, иммуносупрессивных, гормональных, гипогликемичеких, анальгетических, противовоспалительных и нейротропных средств. В представленном обзоре суммируется информация о доклинических и клинических исследованиях, связанных с применением адамантанов для лечения различных сосудистых патологий. Оцениваются перспективы применения мемантина, амантадина, вильдаглиптина и ряда инновационных препаратов для профилактики и лечения церебро- и кардиоваскулярных заболеваний.

Adamantane-type drugs are widely used in pharmacology as antimicrobial, antitumor, immunosuppressive, hormonal, hypoglycemic, analgesic, anti-inflammatory and neurotropic drugs. The review summarizes information on preclinical and clinical studies related to the treatment of various vascular pathologies. Assess the prospects for using memantine, amantadine, a number of innovative drugs for the prevention and treatment of stroke and cardiovascular diseases.

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The authors declare that there are no conflicts of interest present.