phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»phkinetica-21Research ArticleАКТУАЛЬНЫЙ ОБЗОРCURRENT REVIEWSПоведенческие экспериментальные модели депрессииAnimal models of depressionГарибоваТаисия ЛеоновнаGaribovaT. L.T_Garibova@mail.ruКрайневаВ. А.KrainevaV. A.noemail@neicon.ruВоронинаТ. А.VoroninaT. A.noemail@neicon.ruФГБНУ «НИИ фармакологии имени В.В. Закусова»Russian Federation201708072017031419Copyright © Гарибова Т.Л., Крайнева В.А., Воронина Т.А., 20172017Гарибова Т.Л., Крайнева В.А., Воронина Т.А.Garibova T.L., Kraineva V.A., Voronina T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/21

В обзоре приведены и детально описаны основные наиболее используемые поведенческие экспериментальные модели депрессии. Описаны эндофенотипы и критерии валидности поведенческих методов для оценки антидепрессивной активности у соединений. Моделирование депрессии с использованием лабораторных животных позволяет понять природу депрессии у человека и осуществлять поиск эффективных способов её лечения.

The review provides and describes in detail the main most commonly used behavioral experimental models of depression. Endophenotypes and criteria of validity of behavioral methods for evaluation of antidepressant activity in compounds are described. Modeling depression using laboratory animals allows us to understand the nature of depression in humans and to search for effective ways of treating.

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The authors declare that there are no conflicts of interest present.