phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»phkinetica-20Research ArticleАКТУАЛЬНЫЙ ОБЗОРCURRENT REVIEWSМозговой нейротрофический фактор и его низкомолекулярные миметикиBrain-derived neurotrophic factor and its low-molecular mimeticsГудашеваТатьяна АлександровнаGudashevaT. A.tata-sosnovka@mail.ruТарасюкА. В.TarasiukA. V.noemail@neicon.ruПоварнинаП. Ю.PovarninaP. Yu.noemail@neicon.ruСереденинС. Б.SeredeninS. B.noemail@neicon.ruФГБНУ «НИИ фармакологии имени В.В. Закусова»Russian Federation20170807201703313Copyright © Гудашева Т.А., Тарасюк А.В., Поварнина П.Ю., Середенин С.Б., 20172017Гудашева Т.А., Тарасюк А.В., Поварнина П.Ю., Середенин С.Б.Gudasheva T.A., Tarasiuk A.V., Povarnina P.Y., Seredenin S.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/20

Проведён обзор литературы по структуре и физиологическим эффектам мозгового нейротрофического фактора (BDNF). Особое внимание уделено вовлечённости BDNF в патогенез депрессии и подходам к конструированию его низкомолекулярных миметиков.

A literature overview on the structure and physiological effects of the Brain-derived neurotrophic factor (BDNF) has been carried out. Particular attention was paid to the involvement of BDNF in the pathogenesis of depression and approaches to its low-molecular mimetics design.

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The authors declare that there are no conflicts of interest present.