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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">phkinetica</journal-id><journal-title-group><journal-title xml:lang="ru">Фармакокинетика и Фармакодинамика</journal-title><trans-title-group xml:lang="en"><trans-title>Pharmacokinetics and Pharmacodynamics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2587-7836</issn><issn pub-type="epub">2686-8830</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">phkinetica-167</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПОИСК НОВЫХ ФАРМАКОЛОГИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCREENING FOR NEW PHARMACOLOGICALLY ACTIVE COMPOUNDS</subject></subj-group></article-categories><title-group><article-title>Скрининг кардиотропной активности в ряду α, ω-диарилметильных производных бис-(ω-аминоалкил)аминов</article-title><trans-title-group xml:lang="en"><trans-title>Screening of the compounds having cardiotropic activity among the α, ω-diarilmetil derivatives of bis-(ω-aminoalkyl)amines</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крыжановский</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kryzhanovskii</surname><given-names>S. A.</given-names></name></name-alternatives><email xlink:type="simple">SAK-538@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лихошерстов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Likhosherstov</surname><given-names>A. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цорин</surname><given-names>И. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsorin</surname><given-names>I. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Столярук</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Stolyaruk</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вититнова</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Vititnova</surname><given-names>M. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мокров</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mokrov</surname><given-names>G. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гудашева</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gudasheva</surname><given-names>T. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «НИИ фармакологии имени В.В. Закусова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBI «Zakusov Institute of Pharmacology»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>09</day><month>03</month><year>2016</year></pub-date><volume>0</volume><issue>2</issue><fpage>10</fpage><lpage>13</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Крыжановский С.А., Лихошерстов А.М., Цорин И.Б., Столярук В.Н., Вититнова М.Б., Мокров Г.В., Гудашева Т.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Крыжановский С.А., Лихошерстов А.М., Цорин И.Б., Столярук В.Н., Вититнова М.Б., Мокров Г.В., Гудашева Т.А.</copyright-holder><copyright-holder xml:lang="en">Kryzhanovskii S.A., Likhosherstov A.M., Tsorin I.B., Stolyaruk V.N., Vititnova M.B., Mokrov G.V., Gudasheva T.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmacokinetica.ru/jour/article/view/167">https://www.pharmacokinetica.ru/jour/article/view/167</self-uri><abstract><p>Поиск новых оригинальных кардиотропных лекарственных средств, обладающих антарктической и антиишемической активностью, безусловно, является одной из наиболее актуальных задач, стоящих перед современной кардиофармакологией. В рамках решения этой проблемы впервые в ряду α, ω-диарилметильных производных бис- (ω -аминоалкил) аминов был проведён поиск соединений, обладающих подобной активностью.</p></abstract><kwd-group xml:lang="ru"><kwd>screening</kwd><kwd>antiischemic and antiarrhythmic activity</kwd><kwd>ω-diarylmethyl derivatives of bis-(ω-aminoalkyl) amines</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kantor P.F., Lucien A., Kozak R., Lopaschuk G.D. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000; 86: 5: 580-588.</mixed-citation><mixed-citation xml:lang="en">Kantor P.F., Lucien A., Kozak R., Lopaschuk G.D. 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