phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»phkinetica-136Research ArticleАКТУАЛЬНЫЕ ОБЗОРЫCURRENT REVIEWSИзоформа CYP1A2, как составная часть суперсемейства цитохрома P450Isoform CYP1A2, as a part of the cytochrome P450 superfamilyНовицкаяЯ. Г.NovickayaY. G.noemail@neicon.ruЖердевВладимир ПавловичZherdevV. P.zherdevpharm@mail.ruВиглинскаяА. О.ViglinskayaA. O.noemail@neicon.ruЛитвинА. А.LitvinA. A.noemail@neicon.ruФГБУ «НИИ фармакологии имени В.В. Закусова» РАНРоссияFGBI «Institute of Pharmacology named after V.V. Zakusov» RASRussian Federation20140904201401413Copyright © Новицкая Я.Г., Жердев В.П., Виглинская А.О., Литвин А.А., 20142014Новицкая Я.Г., Жердев В.П., Виглинская А.О., Литвин А.А.Novickaya Y.G., Zherdev V.P., Viglinskaya A.O., Litvin A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/136

Описана роль цитохрома Р450 и его изоформы CYP1A2 в метаболизме кофеина. Представлены данные о фармакокинетике кофеина у человека и лабораторных животных. Даны примеры межлекарственного взаимодействия субстратного маркера CYP1A2-кофеина с различными лекарственными веществами.

The role of cytochrome P450 isoforms CYP1A2 and in the metabolism of caffeine is described. Caffeine pharmacokinetics data in humans and laboratory animals are presented. Examples of drug-drug interactions of cubstrate marker caffeine with different drugs are given.

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The authors declare that there are no conflicts of interest present.