phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»phkinetica-13Research ArticleИССЛЕДОВАНИЯ ФАРМАКОДИНАМИКИPHARMACODYNAMICS STUDIESИзучение противофибрилляторной активности соединения ЛМГ-124 и лаппаконитина гидробромида на модели реперфузионных аритмий у крысThe antifibrillatory activity study of the compound LMG-124 and lappaconitine hydrobromide on the reperfusion arrhythmias modelСтолярукВ. Н.StolyarukV. N.noemail@neicon.ruЦоринИ. Б.TsorinI. B.noemail@neicon.ruВититноваМ. Б.VititnovaM. B.noemail@neicon.ruГусевВ. П.GusevV. P.noemail@neicon.ruМуриновЮ. И.MurinovYu. I.noemail@neicon.ruЮнусовМ. С.YunusovM. S.noemail@neicon.ruКрыжановскийС. А.KryzhanovskiiS. A.SAK-538@yandex.ruФГБНУ «НИИ фармакологии имени В.В. Закусова»РоссияFSBI «Zakusov Institute of Pharmacology»Russian FederationФедеральное государственное бюджетное учреждение науки Уфимский Институт химии Российской академии наук (УфИХ РАН)РоссияFSBIS «Ufa Institute of Chemistry of the Russian Academy of Sciences» (UIC RAS)Russian Federation201706032017021618Copyright © Столярук В.Н., Цорин И.Б., Вититнова М.Б., Гусев В.П., Муринов Ю.И., Юнусов М.С., Крыжановский С.А., 20172017Столярук В.Н., Цорин И.Б., Вититнова М.Б., Гусев В.П., Муринов Ю.И., Юнусов М.С., Крыжановский С.А.Stolyaruk V.N., Tsorin I.B., Vititnova M.B., Gusev V.P., Murinov Y.I., Yunusov M.S., Kryzhanovskii S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/13

Сравнительное изучение противофибрилляторной активности соединения ЛМГ-124 и эталонного препарата лаппаконитина гидробромид было выполнено на модели реперфузионных аритмий. Показано, что оба препарата проявляют антиаритмическую и противофибрилляторную активность, однако соединение ЛМГ-124 реализует своё действие в существенно меньшей дозе.

The antifibrillatory activity comparative study of the compound LMG-124 and the reference drug Lappaconitine hydrobromide was performed on the model of reperfusion arrhythmias. Both drugs are shown to exhibit antiarrhythmic and antifibrillatory activity, but the compound LMG-124 realizes its effect in a significantly lower dose.

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The authors declare that there are no conflicts of interest present.