References

phkinetica

Фармакокинетика и Фармакодинамика

Pharmacokinetics and Pharmacodynamics

2587-78362686-8830

ООО «Издательство ОКИ»

phkinetica-124

Research Article

АКТУАЛЬНЫЙ ОБЗОР

CURRENT REVIEWS

Особенности фармакокинетики антисмысловых олигонуклеотидных препаратов

Pharmacokinetics of antisense oligonucleotide drugs

Хаитов

М. Р.

Khaitov

M. R.

noemail@neicon.ru

Смирнов

В. В.

Smirnov

V. V.

noemail@neicon.ru

ФГБУ «ГНЦ Институт иммунологии» ФМБА России, г. МоскваРоссияFGBI «Institute of Immunology» FMBA of Russia, MoscowRussian Federation

2013

09042013

01313

2013

Хаитов М.Р., Смирнов В.В.

Khaitov M.R., Smirnov V.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pharmacokinetica.ru/jour/article/view/124

В обзоре рассмотрены фармакокинетические особенности различных антисмысловых олигонуклеотидных препаратов. Проведено сравнение фармакокинетики препаратов первого и второго поколения. А так же рассмотрено влияние на фармакокинетику химической модификации молекулы.

This review covers the pharmacokinetic characteristics of the various antisense oligonucleotide drugs. A comparison of the pharmacokinetics of drugs first and second generation. As well as the influence on the pharmacokinetics of the chemical modification of the molecule.

антисмысловые олигонуклеотидыфосфотиоатные олигодеоксинуклеотидыфармакокинетикаantisense oligonucleotidesphosphorothioate oligodeoxynucleotidespharmacokinetics

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The authors declare that there are no conflicts of interest present.